SGLT2 inhibitors are new diabetes medicine used to treat type 2 diabetes that are taken by mouth. Such diabetes medicine that helps to lower blood sugar are called as Oral Hypoglycemic Drugs in a common medical terminology. They work by lowering blood sugar and making it easier to control blood sugar levels. Oral hypoglycemic drugs come in many different forms. Some helps to lower the amount of glucose produced by the liver and to improve the sensitivity of the body’s cells to insulin. While some others stimulate the pancreas to produce more insulin.
Diabetes Medicine Group SGLT2 inhibitors
What are SGLT2 inhibitors?
SGLT2 inhibitors are a type of drug used to treat type 2 diabetes. They work by stopping a protein in the kidneys called sodium-glucose cotransporter 2 (SGLT2) from putting glucose back into the bloodstream. By stopping this protein from working, SGLT2 inhibitors reduce the amount of glucose that the kidneys re-absorb and increase the amount of glucose that the body gets rid of through urine. This lowers the amount of glucose in the blood, which can help people with type 2 diabetes better control their blood sugar.
Canagliflozin, Dapagliflozin, and Empagliflozin are all examples of SGLT2 inhibitors. These drugs are often taken with other diabetes medicines, like metformin, to get the best control of blood sugar. One of the drug from this family has recently been approved by the FDA. It’s named as Bexagliflozin. The mechanism of action of this drug is very similar to it’s parent drug family, SGLT2 inhibitors.
Safety Profile of Bexagliflozin (New Diabetes Medicine)
Bexagliflozin is generally thought to be safe, but it can have side effects and risks, just like any other medicine. Some of the most common side effects of bexagliflozin are urinary tract infections, yeast infections, and getting too little water. In a small number of people, bexagliflozin has been linked to diabetic ketoacidosis, kidney problems, and a higher risk of amputations of the lower limbs.
The oral 20-mg sodium-glucose cotransporter 2 (SGLT2) inhibitor is used to help people with type 2 diabetes better control their blood sugar levels. It is not used for people with type 1 diabetes.
Why is Bexagliflozin unique?
Bexagliflozin can be used in adults with an estimated glomerular filtration rate (eGFR) of 30 mL/min/1.73m2 or more. This means that it is effective in controlling blood sugar in people with advanced Diabetic Kidney Disease (Nephropathy).
The dosage recommendation is 20 mg Bexagliflozin to be taken once every morning. and this diabetes medicine is not recommended for the people with persistent dehydration. Approval was based on the results of 23 clinical trials with over 5,000 participants, including more than 300 people with stage 3 kidney disease (eGFR 60 and > 30 mL/min/1.73 m2).
“For adults with type 2 diabetes, the SGLT2 inhibitors have proven to be an extremely useful and one of the best medicine for diabetes. Dr Navneet Goyal, a Critical Care Specialist doctor and the founder of a heathcare startup Sensoriom. “However, the value of newly FDA-approved Diabetes medicine, Bexagliflozin may be limited in patients with Type 1 Diabetes Mellitus and those undergoing Dialysis.”
Diabetes Treatment and Metabolic Syndrome
The risk of developing cardiovascular disease and type 2 diabetes is greatly increased in those who have what is known as “metabolic syndrome,” a collection of symptoms. Excess fat around the waistline, insulin resistance, hypertension, elevated triglycerides, inadequate levels of good cholesterol (HDL), and triglyceride resistance are all examples of these problems.
Maintaining a healthy diet, regularly participating in physical activity, losing weight if necessary, and learning to effectively manage stress are all common treatments and management strategies for metabolic syndrome. It is possible that medications will be prescribed to treat specific symptoms associated with the syndrome.
Effective management of diabetes and metabolic syndrome requires a collaborative effort between the patient and healthcare provider to craft a unique treatment plan.
Medication to control blood sugar and other conditions related to diabetes and metabolic syndrome are common components of treatment. Other lifestyle changes, such as eating well and exercising regularly, may also be necessary. Sometimes, insulin treatment is required as well.
It’s important to keep in mind that the safety and effectiveness of Bexagliflozin will depend on the patient and how their treatment is going. Bexagliflozin’s safety can be affected by the patient’s age, weight, overall health, and other medicines they may be taking.
Because of this, it’s important to see your doctor often while taking Bexagliflozin so that you can keep track of its effects and make sure it’s being used safely and effectively. Your doctor can also tell you if there are any precautions or changes to your lifestyle that you may need to make to lower the risk of side effects and make this medicine safer.